Geological disasters occur frequently along the highways in the Tibetan Plateau, which seriously affects road traffic and threatens the safety of people 's lives and property. It is of great significance to carry out disaster risk assessment and zoning to improve the disaster prevention and resistance capacity of the highway into Tibet. The regional geological environment and disaster development law of the Tibet Highways are summarized, and the macro performance of highway traffic operation is analyzed. On this basis, the Xinjiang Tibet Highway is taken as the research object, and the evaluation factors are selected according to the regional geological environment and the main controlling factors of meteorological disasters. Using the information model based on multi-source data fusion, a risk assessment model for water damage disasters, geological disasters, and comprehensive disasters along the Xinjiang Tibet Highway is established. Different evaluation factor information values are obtained, and the susceptibility assessment map, hazard assessment zoning map, and comprehensive hazard risk assessment zoning map of water damage disasters and geological disasters along the Xinjiang Tibet Highway are drawn. The final geological hazard high and extremely high-risk areas contain 96.09% of known geological hazard hidden points, while the water damage hazard high and extremely high-risk areas contain 94.74% of known water damage hazard hidden points. The comprehensive disaster risk assessment zoning map shows that the high and extremely high-risk areas contain 95.76% of known disaster hidden points, which can truly reflect the risk status of road disasters in Tibetan areas and verify the effectiveness of the method.