In order to study the seismic macro-failure process and dynamic response characteristics of rock slope with muddy interlayer,and reveal the influence of muddy interlayer on slope stability, a similar slope model with concave and convex slope types was designed,shaking table test was carried out,and finite element analysis was used for numerical modeling analysis,and the results obtained by the two models were compared.The results show that:The macroscopic deformation and failure process of the model slope is as follows:①Mud interlayer dislocates and cracks occur;②Mud interlayer slips and cracks expand;③Slope collapse.The earthquake has a decisive factor on the stability of the slope.With the increase of the earthquake load,the peak acceleration of the slope increases and the damage becomes more serious.In the testthe clay interlayer is the first to appear tensile crack,which is the weak part of the slope and the important reason for the slope instability induced by earthquake load.The seismic acceleration response characteristics of the two slopes are as follows: with the increase of seismic load, the PGA amplification coefficient of the two slopes first significantly increases and then slowly decreases.The curve trend of PGA amplification coefficient is basically the same. The values near the third layer interlayer and at the slope shoulder are significantly higher than other measurement points.The PGA amplification factor of concave slope is slightly larger than that of convex slope,and the trend of broken line is more tortuous,showing more complicated amplification effect. Numerical simulation of slope instability and failure under seismic acceleration amplitude of 0.6g.The failure modes of concave and convex slopes are slightly different.The failure modes of concave slopes are:slope shoulder collapse,sliding failure near the changing slope point;The failure mode of convex slope is:slope line collapse failure.The seismic stability of convex slope is slightly better than that of concave slope.