In order to study the effect of the change in the master curve parameters of the dynamic modulus of asphalt mixture and the interaction on the structural response of asphalt pavement,a three-dimensional model of the asphalt pavement structure was established using the finite element method,and the structural calculations of asphalt pavement with semi-rigid base and flexible base were carried out.The master curve parameters of the dynamic modulus δ,α,β,and γ were taken as the influencing factors,and the maximum tensile strain at the bottom of the asphalt layer and the vertical compressive strain at the top of the subgrade were set as the response targets.The response surface model of the master curve parameters of the dynamic modulus and the critical structural response of the asphalt pavement was established by the response surface method (RSM ),and the influence of the master curve parameters and their interaction on the critical response of the asphalt pavement structure was analyzed.The results show that the effect of the master curve parameters of the dynamic modulus on the critical response of the structure is influenced by the type of response and the type of pavement structure,and the parameter δ has the greatest effect,followed by α.The effects of β and γ are relatively small.The tensile strain at the bottom of the asphalt layer and the vertical compressive strain of the subgrade of the pavement structure with a semi-rigid base are not affected by the interaction between parameters,and the interaction of parameters α and β has a significant effect on the vertical compressive strain of the subgrade of the pavement structure with a flexible base.