Based on the engineering background of Hainan Nandu River Bridge, the three-dimensional finite element dynamic model of the bridge is established. Firstly, the selection of ground motion input and the establishment of finite element model are introduced. Secondly, the influence of different design parameters (bearing radius) of friction pendulum vibration reduction and isolation bearing on the seismic response of the bridge is discussed, and the optimal bearing parameters suitable for the bridge are obtained; Finally, the seismic responses of the bridge under three different restraint structures, namely, conventional restraint system, friction pendulum bearing vibration reduction and isolation system and rigid frame bridge system, are compared and analyzed. The results show that the vibration reduction and isolation system with friction pendulum bearing can not only greatly reduce the seismic response of the whole bridge structure under transverse or longitudinal seismic input, At the same time, the displacement response can be controlled within a reasonable range, which proves that this seismic system is very effective for the bridge.