As an important stone resource in China, granite is widely used in the preparation of machine-made sand and other building materials due to its stable physical properties and favorable mechanical performance. In order to promote the better application of granite in machine-made sand for cement concrete, this paper analyzed the mineral composition, particle grading, and mica content of granite machine-made sand. It systematically summarized the influence of these characteristics on the mechanical properties, durability, and volumetric stability of concrete. The results show that the concrete performance declines with increasing mica and stone powder content in granite machine-made sand. Properly limiting their content can improve the mechanical properties and durability of concrete. Based on existing research, this paper also discusses problems such as excessive mica content in granite machine-made sand, providing a reference for its further application in cement concrete.